국립암센터 면역세포유전자치료제전주기기술개발연구단

R&D

Opening New Possibilities in Therapeutics for Hard-to-Treat Solid Tumors

Research Programs

Clinical Research on Neoantigen-Reactive TILs

Tumor-infiltrating lymphocytes (TILs) are T cells that infiltrate tumor tissues. TILs can be isolated from a patient’s tumor tissue and expanded ex vivo before being reinfused into the patient to induce an antitumor immune response.

Evaluation Criteria

Safety
Immune Response
Antitumor Activity

Assessing the Clinical
Feasibility of Personalized
TIL Therapy

This clinical research aims to evaluate the safety, immune response, and preliminary antitumor activity of neoantigen-reactive TIL therapy to assess the clinical feasibility of personalized TIL therapy.

R&D

Project Overview

Explore each research project.

TIL

National Cancer Center

Research Overview

TIL / Solid Tumors (Basket Trial)
Indications
Unmet need for advanced TIL manufacturing

Bulk TIL therapy has demonstrated limited efficacy in patients with refractory metastatic epithelial cancers,
whereas neoantigen-reactive TIL therapy has shown clinical responses in approximately 12% of treated patients.
Basket Trial Design

Clinical studies are conducted across multiple tumor types based on the same therapeutic mechanism of TIL therapy

TIL 치료는 신생항원을 인식하고, 종양미세환경에 존재하던 T세포를 이용함
TIL 제조는 동일 제조 플랫폼 내에서 암종별로 차이가 없음
TIL Manufacturing Workflow

Research
Status

Manufacturing Process Development & Nonclinical Studies

Currently, nonclinical studies are being conducted for manufacturing of unselected TILs and enhanced TILs, including research on the manufacturing process of neoantigen-reactive TILs. As of July 2025 (status as of July 2025)
※ Tumor-Infiltrating Lymphocyte (TIL)
Tumor-infiltrating lymphocytes (TILs) are T cells naturally residing within the tumor microenvironment.
TIL therapy involves isolating these tumor-reactive lymphocytes, expanding them ex vivo,
and reinfusing them into the patient to induce antitumor immune responses.